Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate
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منابع مشابه
Analogs of diadenosine tetraphosphate (Ap4A).
This review summarizes our knowledge of analogs and derivatives of diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A), the most extensively studied member of the dinucleoside 5',5"'-P1,Pn-polyphosphate (NpnN) family. After a short discussion of enzymes that may be responsible for the accumulation and degradation of Np4)N's in the cell, this review focuses on chemically and/or enzymatically produced...
متن کاملEndogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue.
Diadenosine polyphosphates have been characterized as extracellular mediators controlling numerous physiological effects. In this study, diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate were isolated and identified in human myocardial tissue. Human myocardial tissue was homogenized and fractionated by affinity chromatography, displacement chromatography, ani...
متن کاملDiadenosine Tetraphosphate Hydrolase from Mouse Liver
An enzyme hydrolyzing diadenosine 5’,5”’-P1,P4-tetraphosphate (Ap4A) to AMP and ATP has been purified to apparent homogeneity from mouse liver cell extracts. The isolation procedure comprised ammonium sulfate precipitation, chromatography on Sephadex G75, DEAEhellulose, blue Sepharose and AMP-Sepharose. The enzyme is a single polypeptide chain with a native M, = 64,000 with a K,,, of 1.66 PM an...
متن کاملThe Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate.
To determine the role of the FHIT tumor suppressor gene product, a diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) hydrolase, in the regulation of the concentration of Ap3A and diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) in vivo, the levels of the adenosine(5')triphospho(5')nucleoside (Ap3N) and adenosine(5')tetraphospho(5')nucleoside (Ap4N) families were measured by luminometry in a number o...
متن کاملStructural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase.
Malaria symptoms are driven by periodic multiplication cycles of Plasmodium parasites in human red blood corpuscles (RBCs). Malaria infection still accounts for ~600,000 annual deaths, and hence discovery of both new drug targets and drugs remains vital. In the present study, we have investigated the malaria parasite enzyme diadenosine tetraphosphate (Ap4A) hydrolase that regulates levels of si...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1995
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1995.tb16382.x